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PSYCH Symposium: exploring eating disorders and psychedelics

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Now is the time for psychedelic access, says campaigner

PSYCH Symposium is returning at the British Museum on 6 July, when a panel of experts will discuss how psychedelics could innovate eating disorder care.

With the prevalence of eating disorders increasing by 140% in the last 10 years, there is a desperate need for innovative approaches to eating disorder care.  

PSYCH Symposium’s panel, ‘Treating Eating Disorders: Building Patterns & Reducing Prevalence’ will explore how psychedelics can create potential mechanisms for the brain to cope with the key triggers of such conditions.

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We spoke to panel members, Professor Rebecca Park, Associate Professor & Honorary, Consultant Psychiatrist at Oxford University and Yoel Golbert, Co-Investigator at Sheba Medical Center Department For Eating Disorders, ahead of the event to find out more. 

What does the current landscape look like for eating disorder treatment and what does current research show about the potential of psychedelics as a supportive treatment for such conditions?

R & Y:  Anorexia Nervosa (AN) has the highest morbidity and mortality of any psychiatric disorder and is arguably the most challenging psychiatric disorder to treat, with no proven drug treatment of benefit.

There is evidence for specific forms of psychological treatment (in particular a specific Family-based treatment in adolescents with a short duration of illness, and CBT-E/MANTRA in adults ill less than 3 years and not severely underweight ). However sadly around a third of adults do not recover fully and a further third remain stuck in their illness at huge cost to lives, families, and healthcare systems. 

AN also has high levels of Comorbidity, especially with OCD, Depression and Anxiety disorders, which need treatment in their own right. Thus, innovation to develop novel evidence-based treatment is urgently needed. 

See also  PSYCH Symposium: the future of psychedelic medicine in the EU

Current research into psychedelic therapy for ED is novel, with a cautiously emergent evidence base.

In particular, preliminary results from open trials suggest that psilocybin-assisted psychotherapy can help alleviate ED pathology in those with AN. While this is encouraging, it needs to be proven in controlled trials. 

Further research into mechanisms of effect, patient selection,  and the role and format of therapeutic support is also urgently needed.  Clinical trials need to balance the delicate  risks of benefits vs harms, especially of short-term interventions, as the road to recovery from AN is long and hard, commonly  taking  several years 

What are the potential risks, challenges and benefits of using psychedelics as a therapeutic tool for individuals with eating disorders? What are your thoughts on how any challenges or risks can be tackled? 

R & Y: The risks, challenges and benefits stakes are highest for individuals with AN. Risks are especially high for those severely underweight and/or binge-purging, who are often physically and emotionally fragile and have medical complications which need to be taken into account. 

These patients need particularly high levels of monitoring, support, and containment in the journey through a psychedelic experience. Many will have been relatively cut off from intense emotion and their appetites, due to deficits in interception and body awareness for years or even decades. 

Difficulties in emotional regulation are common in those with eating disorders, whose eating disorders behaviours such as extreme dietary restriction paradoxically can serve as a protective mechanism, a means to disconnect from overwhelming core emotions.

Experiencing intense emotions and appetites as part of a psychedelic experience may thus be frightening or overwhelming to them if not expertly contained and supported. Patients need ongoing trusted support through their journeys and it is essential practitioners and researchers are mindful of these risks. 

If not supported through this, patients may experience the start of the process of recovery as getting worse, rather than part of a process of getting better- and will be at risk of retreating back into ED behaviours as a way of coping.

How do psychedelics impact body image perception and self-esteem, which are often distorted in individuals with eating disorders?

R & Y: Psychedelics alter the perceptual experience and is hypothesised that MDMA and psilocybin may serve as an empathogen, reducing self-criticism whilst inducing a sense of compassion and connection to the self and others. This in turn might harness a self-perspective that is later worked on in integration and therapy. Widening the “window of tolerance“ of complex and overwhelming emotions may also foster a better foundation for therapy and nutritional support. This is crucial in a patient population that is notoriously ambivalent to treatment.

In Anorexia especially, body image is very strongly related to self-evaluation, self-image and self-esteem. Therefore, the hope would be that a more compassionate perspective of the self and of the body can in turn promote motivation and support recovery. Psilocybin can induce new insights, and enhance a sense of embodiment and personal meaning. 

These effects might potentially help improve insight and body image in those with AN, who often have deficits in interoception and lack a sense of embodiment.

Are there any specific psychedelics that have shown promise in addressing the underlying psychological factors contributing to eating disorders?

R & Y: Regarding peer-reviewed research, data is still emergent, with several studies in progress. Psilocybin has shown some benefit from preliminary findings of open studies and has a good safety profile, which is important, especially in AN. 

Controlled trials are now underway in AN. Evidence from studies such as depression suggest psilocybin can enhance flexibility, openness for change, reduce rumination and improve cognitive flexibility and sociability. 

These effects could provide a strong foundation for additional therapeutic strategies in AN. Studies of MDMA in eating disorders are now underway, given it was found to reduce self-reported ED symptoms in an open study of PTSD .

Its anxiolytic-pro-social effects could also potentially provide a strong bedrock for adjunctive psychotherapies.

PSYCH Symposium’s panel ‘Treating Eating Disorders: Building Patterns & Reducing Prevalence’ will also include panel member Rivki Stern, CEO at Short Wave Pharma – a sponsor PSYCH Symposium sponsor – and moderator Claudia Canavan, Health Editor at Women’s Health.

Psychedelic Health is offering readers 10% off tickets for PSYCH Symposium. To claim your discount click here and use the code PSYCHHEALTH10. 

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Psychedelic-assisted therapy for treating PTSD in Ukraine brings hope

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Photo by Karollyne Videira Hubert on Unsplash

The war in Ukraine brings suffering and trauma, which naturally leads to cases of post-traumatic stress disorder (PTSD) among soldiers and civilians. The Ministry of Health of Ukraine predicts that about 4 million Ukrainian civilians are suffering from PTSD.

According to the WHO, about a quarter of the Ukrainian population may be affected by disorders of mental health. In order to deal with this challenge, Ukraine must ensure access to safe, effective and adequately regulated therapy.

That is also why Ukraine is trying to support the idea that mental health will become an integral part of Ukraine’s “reconstruction.” Czech Republic can in this regard offer a helping hand in the sphere of innovative therapy. That is also one of the reasons why a Ukrainian delegation took part in the international conference Novel Mental Health Treatments and Sustainability of Healthcare Systems: Czechia as a Leader of the EU? which took place in Prague.

Psychedelic-assisted therapy is being increasingly discussed in Ukraine as a way of treating PTSD. Although the use of ketamine as part of mental illness treatment has been legal since 2017, substances such as MDMA and psilocybin are still banned. With a view to global development, which has been inching towards supporting the medical use of psychedelics, Ukrainian institutions are supporting clinical studies for psychedelic-assisted therapy as an innovative way of treating PTSD.

Medical use of psychedelics in PTSD treatment in Ukraine

The potential of psychedelic-assisted therapy in the context of the war in Ukraine was also the focus of one of the conference panels. The panel was attended by Ukrainian MPs Mykhailo Radutskyi, Dmytro Gurin, Rostyslav Tistyk and State Secretary of the Ministry of Internal Affairs Inna Yashchuk.

Over the course of the day, Mykhailo Radutskyi, Member of the Verkhovna Rada of the Parliament of Ukraine and Chairman of the Committee on National Health, Health Care and Health Insurance praised the Czech Republic and said that the country is at the forefront of psychedelic research in Europe.

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“We have a large population suffering from mental health problems, but we will most likely never have enough experts. In Ukraine, we have an information campaign on how to treat soldiers who have returned from the front, and we are proposing a law which would ensure mental health,” Radutskyi stated.

“About 3.5 million people in Ukraine, and not only soldiers and veterans, currently have mental health problems because of the war, over a million war veterans will need psychotherapeutic help, and currently about half of the veterans suffer from PTSD,” said Dmytro Gurin, Ukrainian MP and member of the Committee on National Health, Health Care and Health Insurance.

“Mental health must become an issue and must play a part in the reconstruction of Ukraine. Winning the war is one thing, but we must also win the war on mental health. One way to win this war is through psychedelic-assisted therapy, and our Parliament and the Ministry of Health will support clinical trials.

“I hope that we will soon approve a study researching the potential for treating PTSD through psychedelic-assisted therapy. Our task is to create fitting conditions for future clinical trials.”

State Secretary of the Ministry of Internal Affairs Inna Yashchuk said: “The Ministry of Internal Affairs is setting up mental health centers all over Ukraine, and I estimate that when we win, 80 % of the people will come to their doctors in need of psychological and psychiatric help. So mental health is not a problem today, but it will be a problem for the future.”

Czech Republic wants to help Ukraine with mental health issues

The event also featured a speech by the Governmental Envoy for the Reconstruction of Ukraine, Tomáš Kopečný, who said: “Ukraine’s reconstruction is not only about physical reconstruction, but also about the mental health of Ukrainian civilians and war veterans, it is about increasing capacities on site, so that the support reach is as effective as possible.”

Other experts also believe that one of the outcomes of the panel discussion should consist in the establishment of a structural relationship between the Czech Republic and Ukraine in the field of mental health, which would include scientific cooperation, exchange of know-how and joint research projects.

Scientific supervision of the ongoing exchange between Czechia and Ukraine in the field of mental health is primarily provided by Professor Jiří Horáček of the Faculty of Medicine at Charles University and director of the Centre for Advanced Studies of Brain and Consciousness at the National Institute of Mental Health, who has prepared an innovative clinical study of using ketamine for the treatment of PTSD in Ukrainian veterans.

In Czech Republic, the topic is also addressed by the Psychedelic Research Foundation (PSYRES). Its director, Jana Bednářová, has said that: “Research about psychedelics is crucial for the future of Ukraine and the Czech Republic. While such research will put Czech Republic on the cutting edge of the field in Europe, without breakthrough solutions for Ukraine, it can take an entire generation to regenerate mental health – in comparison, the physical recovery of the country can be a matter of mere years. Our mission is to enlist visionaries, philanthropists, organizations and the general public to support our research projects and activities and help us make treatment available to everyone who may need it.”

The issue has been resonating in Brussels, Czechia among EU leaders in mental health

The Czech Republic was the first country to put mental health back on the EU’s agenda. The Czech trial in Brussels also leads to the topic of psychedelic-assisted therapy in the treatment of PTSD in Ukraine. The topic was first addressed last year by PsychedelicsEUROPE, a platform focussing on the European regulation of psychedelics. The platform has long been working towards the approval of a new regulatory framework for the medical use of psychedelics on the European single market.

“Mental health is becoming a central issue for the EU. We are a little behind the US, the UK and Australia, but the necessary debate about the regulation of psychedelic substances is coming to Europe. In the same way that psychedelic-assisted therapy can help Ukraine, Ukraine can help the EU in this field by providing data from new research which may help with drafting good legislation. This is one of the reasons why mental health ought to be an implicit part of Ukraine’s reconstruction,” said Viktor Chvátal, founder of PsychedelicsEUROPE.

The event was organised by:

PSYRES
The mission of PSYRES, the Psychedelic Research Endowment Fund, is to provide funding to scientific projects and facilities that focus on innovative treatment procedures in the field of mental illnesses. Our task is to support research and study of the potential of psychedelics and their therapeutic use in psychiatry, neurology and addictology. Our activities help with the preparation and implementation of clinical studies and analyses and with the education of the public. We collaborate with doctors, therapists and researchers who deal in depth with altered states of human consciousness.

INSTITUTE FOR RATIONAL ADDICTION POLICIES
Institute for Rational Addiction Policies is a multidisciplinary association of independent and prominent experts who address the issue of addiction from all angles – public and individual health, legislation and other legal implications, including security challenges, and economics including market modeling, tax, economic impacts on public budgets, the field of education and prevention, and finally also the fields of social and sociological and political science.

PSYCHEDELICS EUROPE
PsychedelicsEUROPE (PE) is an innovative public affairs mental health platform based in Brussels that brings together leading research centres, NGOs, investors, philanthropists and private companies. Based on the latest scientific evidence, PE advocate in the EU for a regulatory environment that promotes modern therapies, cutting-edge research, and innovative industry.

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Psychedelic therapist training programmes are not fit for purpose

We must learn from our mistakes when conducting Psychedelic Assisted Therapy.

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Groundbreaking trial to assess real-world efficacy of MDMA therapy for PTSD

Psychologists, therapists and counsellors play a fundamental role in treating common mental health disorders such as anxiety and depression. With little advancement in treatments for common mental health issues for over half a century, reliance on therapy to support people with such conditions is extremely high in the UK.

However, most training programmes for these professionals do not focus enough on skills acquisition and we are simply not training enough therapists to meet the growing demand. This will not fix the nation’s mental health crisis.

Don’t believe me? Look at the variance in outcomes between therapists. Look at the sheer number of people in England who are prescribed antidepressants by their GP. The figure now stands at more than 8 million people, with over 2 million having been taking them for five years. Look at the number of people on waiting lists to start therapy. It all points to a fundamental problem where many people, with a common mental health problem, are unable to access therapy that works.

One of the reasons lies in the way we train therapists. On most training programmes, students are assessed as competent to practice through their academic writing and the submission of one or two, self-selected, recordings of therapy sessions. They typically have a placement to apply their new skills. However, unlike other healthcare professionals, these sessions occur behind closed doors, without direct observation. Imagine training a nurse, a surgeon or a dentist like this.

See also  Where can I find training for psychedelic therapy?

This lack of direction observation makes it difficult to know what the trainee is doing with their patients, whether they can consistently deliver therapy with fidelity to the therapy model, and how they interact with patients/clients. It makes it difficult to give the trainee meaningful feedback that will enable them to become better at what they do.

The system encourages higher and higher academic qualifications. However, in my own experience of teaching and supervising mental health professionals, there is no association between competence and the level of academic qualification. Dare I say it, but it is not necessary to have a degree in order to be a highly effective therapist.

This is why Clerkenwell Health has recently launched their Foundations Programme – a practitioner programme for healthcare professionals interested in Psychedelic Assisted Therapy (PAT). Programme participants will be provided with the knowledge required to prepare to safely, ethically and effectively deliver psychedelic treatments.

As we move towards a future where Psychedelic Assisted Therapy (PAT) becomes more mainstream in treating metal health disorders, we must ensure all training programmes robustly assess whether a trainee can consistently deliver high quality therapy that makes measurable difference to patients’ lives. This is what really matters.

Clerkenwell Health’s Foundations Programme leaves no stone unturned. The course explores both the ethical and practical aspects surrounding psychedelic treatments within a regulated healthcare setting, with the teaching delivered by practitioners at the forefront of psychedelic research in the UK, including Dr Sara Tai, Professor of Clinical Psychology at the University of Manchester; Dr David Luke, Associate Professor of Psychology; and Dr Jules Evans, the writer, philosopher and award-winning author of Philosophy for Life.

I asked one organisation, that provides training in PAT, how they selected their trainees, and I was told that it was done “with the gut”. The current approach runs the risk of training a new workforce who are not fit for purpose.

What’s more, all of the existing programmes use ‘psychedelic-psychobabble’. Trainees are taught to ‘trust the medicine’, ‘trust your instinct’ or ‘trust that the participant has the power to heal themselves’. These terms are not widely understood within mainstream healthcare and have, in some cases, led to acts of gross misconduct.

We need a more sober, science-led and evidence-based approach to training. Clerkenwell Health’s Foundations Programme tries to achieve this by providing learners with a thorough background in the history, current state of evidence, treatment modalities, putative mechanisms of actions, and future of psychedelics.

Patient safety, robust standards and clinical effectiveness are of utmost importance in our work at Clerkenwell Health. It’s for these reasons that we’ve launched the Foundations Programme, a course which carefully selects its trainees, assesses their competence and efficacy and is scientifically and theoretically robust. This is not the place where you can try out some psychedelics and suddenly feel qualified to be a psychedelic assisted therapist. This is the place where healthcare professionals come to train in evidence-based practices that are proven and safe. PAT must grasp the golden opportunity to set the standard for a new paradigm in mental healthcare.

If you’re interested in learning more about Clerkenwell Health’s Foundations Programme, you can find out more here: https://training.clerkenwellhealth.com/foundations

This article was written by Dr Sarah Bateup, Scientific Advisor at Clerkenwell Health. Sarah has delivered over 30,000 hours of therapy and taught at Kings College London and Exeter University before joining ieso digital health where she helped scale the company from 10 therapists to 1000.

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Psilocybin therapy for end-of-life care supported by 79% of Canadians

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The Entourage Effect in Mushrooms: Natural psilocybin may outperform synthetic

A new survey has revealed that over 79% of Canadians support psychedelic-assisted therapy for existential distress at the end of life.

People facing a terminal diagnosis often experience significant distress. Depression, anxiety, existential distress and loss of meaning or purpose can make this type of diagnosis difficult to deal with.

Current treatments consist of counselling of cognitive behaviour therapy (CBT), but these are not always effective for everyone, creating a need for innovative new approaches to end-of-life care.

Increasing research is now showing that psychedelic therapy may be beneficial for treating existential distress in patients diagnosed with incurable diseases.

For example, a review published in 2018 in Neuropsychopharmacol Biol Psychiatry found that patients with life-threatening diseases associated with symptoms of depression and anxiety benefitted from the anti-anxiety and anti-depressant properties of psychedelics.

The studies reviewed anecdotally reported that patients experienced quality of life improvements along with a reduced fear of death.

A randomized double-blind trial carried out by John Hopkins University also revealed that high-dose psilocybin produced significant decreases in depression, anxiety and death anxiety, and improvements in quality of life, life meaning, and optimism.

A further clinical trial from New York University found that 60% to 80% of participants experienced anti-anxiety and anti-depressive effects from the treatment, along with benefits for existential distress, quality of life, and attitudes towards death, noting that “the psilocybin-induced mystical experience mediated the therapeutic effect of psilocybin on anxiety and depression.”

Supporting psychedelics for end-of-life care

In light of psychedelic therapy’s inclusion in Canada’s Special Access Programme in 2022, which enables authorised patients to receive access to these therapies if other treatments have been unsuccessful, a team of researchers set out to understand the public’s opinion on the potential easing of rules surrounding the medical use of psilocybin.

The survey, published in Palliative Medicine and carried out by Michel Dorval and Louis Plourde at Université Laval’s Faculty of Pharmacy and researchers from McGill University, Université de Montréal and UQAR, revealed that nearly four out of five Canadians support the use of psilocybin as a treatment for end of life existential distress.

In a statement, Dorval commented: “Studies have already shown that psilocybin, combined with psychotherapy, produces rapid, robust and lasting anxiolytic and antidepressant effects in patients suffering from advanced cancer.

“This substance can bring about a profound awareness that leads the patient to view existence from a different perspective. Treatment with psilocybin, combined with psychotherapy, can produce relief for up to six months.

“Our results seem to indicate that the social acceptability of this intervention is high in the Canadian population. If we consider only Québec respondents, the acceptability rate is similar to the national average.”

The findings also revealed that public support for psilocybin is higher among respondents who have already been exposed to palliative care, as well as higher in respondents who have already used psilocybin.

“Having been close to loved ones at the end of life, or having witnessed their distress, could explain this openness to new approaches designed to help people at this stage of their life,” added Dorval.

“There are still many prejudices against psychedelic substances. Familiarity with these substances probably helps to better understand their true effects as well as their therapeutic potential.”

The authors write: “The social acceptability of psilocybin-assisted therapy for existential distress at the end of life is rather high in Canada. These findings may contribute to efforts to mobilise resources and improve access to this emerging therapy in palliative and end-of-life care settings.”

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Psychedelic Health is a journalist-led news site. Any views expressed by interviewees or commentators do not reflect our own. We do not provide medical advice or promote the personal use of psychedelic compounds. Please seek professional medical advice if you are concerned about any of the issues raised.

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