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Majority of UK MPs support drug policy reform

A new report has revealed the majority of MP’s support evidence-based drug reform.

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Majority of UK MPs support drug policy reform

A new report from the Conservative Drug Policy Reform Group (CDPRG) has shown the majority of MPs in the UK support drug policy reform, and highlights how current policy is a barrier to psychedelic research – restricting the development of new medicines.

As the rest of the world moves towards more progressive approaches to drug policy, the UK announced a ten-year crackdown on drugs. Dubbed the ‘overdose capital of Europe’, the UK’s new policy would see a record amount of funding funneled into reducing addiction and drug-related crime.

The new report from the CDPRG, ‘Making UK Drug Policy A Success: Reforming The Policy Making Process’, shows that the majority of MP’s from all parties want evidence-based reform in the UK – something the new government strategy is lacking. It also emphasises that the UK needs to rewrite its policymaking process for drugs.

The report says that the strategy, informed by the independent Dame Carol Black review, is confused between its approaches to problematic and non-problematic drug users, and “potentially places yet more burden on a criminal justice system that is already swamped by drugs-related work, serving to drive drug users even closer to their criminal supply chain and away from the treatment and security the state should offer.”

Time for evidence-based reform

The CDPRG polled MPs in June 2021, revealing that 72 per cent of Conservative MPs agree the process of making drug policy should make more use of evidence and research. 

It also showed that 85 per cent of Conservative MPs, and 90 per cent of all MPs, agree that improved cross-departmental coordination would better in helping to tackle the health crime and social problems associated with controlled drugs.

The recommendations in the report are informed by two round tables – one in collaboration with the Institute for Government and one co-chaired by Drug Science – as well as the most comprehensive analysis of UK drug policy to date. This analysis was carried out by the UK Drug Policy Commission almost ten years ago in 2012 and still remains relevant today.

CDPRG director of research, Dr Toby Webster, commented: “We’ve taken [from the analysis] the already established lessons of how drug policy should be made if it is to have a chance of achieving its stated objectives.

“The drug strategy is more complete in some areas than others – there will be a considerable amount of ongoing development, particularly in those areas for which they didn’t carry out a decent, formal, independent consultation, which is essentially everything except for treatment for addiction.

“Carol Black’s review of drugs part 2 covered the treatment of addiction very thoroughly, and it was clearly a useful resource for the team drawing up this strategy, as is reflected in the quality and detail of the recommendations they make in this area. There remains the opportunity for more formal consultation to improve the plans that are still being drawn up, and this is something we will be advocating for.

“As we engage with the ongoing development of the drug strategy, we hope to emphasise the principles of good governance that we present in our report, and we hope that this can be of some use – good policymaking processes lead to better policies, and this is what we hope to see.

“We are overall optimistic that there is an understanding that evaluating these policies properly, and having proper accountability, is key to making sure that we don’t continue the failings of the past, and we hope that this is maintained.

“We hope that the government’s commitment to evaluation and developing more sensible outcome measures leads to a willingness to admit and learn from mistakes, and change course if efforts are not working”.

The Government’s aim in its new strategy to help people reduce their reliance on addictive substances has generally been welcomed, but evidence-based drug reform groups said the new measures did not go far enough.

Drug Science urged the Government “to change its approach completely, and to adopt a rational, evidence-based approach of drug control”.

Responses also raised concerns that many of the initiatives listed are against evidence and will cause further harm.

See also  Reform organisations respond to new UK drug strategy

This sentiment from MPs and reform groups is an echo of the UK public’s views, with public polling from 2019 showing that only one in four adults believe current UK drug policy is effective at preventing harm to health and wellbeing, and three in four believe that criminal sanctions do not deter either drug use or supply. 

Additionally, a public survey carried out by YouGov earlier this year showed majority support for the rescheduling of psilocybin for research and medical purposes.

“The UK has made insufficient efforts to keep regulations up to date with the evidence base, and has been slow to respond to emerging information,” states the report.

See also  Majority in favour of changing law to boost psilocybin research in UK

Reforming the policymaking process

The report underlines the need for the UK to rewrite the policymaking process itself, saying that a methodologically flawed process sits behind the UK’s drug crisis.

Chair of the CDPRG MP Crispin Blunt says reforming this process is a “crucial foundation for producing better drug policy in years to come”.

Highlighting the inadequate capacity to carry out research that can inform policy creation as the principal problem, the report puts forward recommendations on how this can be changed.

“This is compounded by there being no specification on the extent to which policymaking must make use of evidence,” it states.

“COVID-19 has irrevocably increased awareness that the political and collective response to public health crises is best when guided by good science.”

However, the Government currently does not extend this to its drugs policy.

The 23 recommendations include suggestions to: 

  • Develop a National Drug Research Strategy
  • Establish a National Institute for Drug Science to coordinate research into substance misuse
  • Pilot schemes of new and innovative approaches such as harm reduction initiatives

They also include recommendations to ensure the Ten Year Drug Strategy is effective, suggesting that:

  • It should define specific, measurable and achievable goals, so that it can be clearly evaluated and held to account
  • It should include a robust outcome framework with evidence-based logic models informed by an open consultation 
  • It should clearly and simply outline the responsibilities of every involved department for achieving each specific commitment, and
  • It should outline the total projected expenditure including budgetary commitments of each spending department, and any funding which is to be ring-fenced for specific purposes

MP Crispin Blunt commented: “UK drug policy frequently misses its mark and our outcomes are among the worst in Europe for good reason.

“It has been apparent for some time that the way we make drug policy is not fit for purpose – indeed it is often chaotic and contradictory, barely evaluated, and with a distinct lack of senior accountability for the failures it has produced. This leads to an endless repetition of the same worn-out approaches, and outright denial from the top as they persist with strategies and legislation that has barely changed in 60 years.

“I am pleased to present our new report that shows in detail how poor policymaking has led to poor policies and poor outcomes, and recommends some steps towards improving this process.

“We are glad to see some acknowledgements of past failures in the government’s new drug strategy, and some more emphasis on data and evidence in taking the next few steps, but it remains to be seen if this will translate into concrete action.”

See also  Calls for UK Government to pilot Overdose Prevention Centres

Hindering scientific research

The new report highlights the current renaissance in psychedelic research – much of which, after 50 years of scientific censorship, is gleaning new insights into addiction and resistant mental health conditions. 

It notes the current barriers around the research of psychedelics such as psilocybin and MDMA in the UK – pointing out the multibillion market that is developing in this area across the globe.

“With over 50 psychedelics companies publicly listed across a number of exchanges, including the NYSE and NASDAQ, their combined market caps exceed $6bn,” states the report. 

“One of the largest of these companies is the UK-based Compass Pathways, but despite this and due to the harsh regulatory environment, there are currently no psychedelic companies at all listed on the London stock exchange.”

The CDPRG’s report, ‘Medicinal Use of Psilocybin’ shows there is little evidence of a social benefit to the current controls, and that there is now clear evidence these controls have actually slowed the development of new medicines.

The organisation, which has been campaigning for 24 months to reschedule psilocybin from Schedule 1 to Schedule 2, stated: “Returning to the ‘moral purpose’ and the spirit in which they were written, our drug laws should not inhibit the development of medicines.”

It continues: “The Home Office has been resistant to consulting the ACMD on the aforementioned scheduling of psilocybin for the purposes of facilitating medical research in the substance in the UK, despite the Home Office confirming that the substance (and a number of other controlled drugs) have not been subject to analysis or recent analysis of harm.

“The issue of the relationship between the Home Office, ACMD and use of evidence, in general, is contentious, with concerns that short term political priorities are taking precedence over evidence.”

To read the full report please visit: www.cdprg.co.uk

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Policy

EMA workshop: One small step for Europe, one giant leap for psychedelics

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EMA workshop: One small step for Europe, one giant leap for psychedelics

In a watershed moment for psychedelics in Europe, the European Medicines Agency (EMA) held a workshop from 16 to 17 April to discuss regulatory guidelines for the development and therapeutic use of psychedelic medicines.

2024 is set to be an important year for psychedelics and the EMA multi-stakeholder workshop is just one of the key events kicking it into action.

The two-day workshop – Towards an EU Regulatory Framework – brought together patients, healthcare professionals, academia, regulators and industry.

As Europe risks lagging behind countries such as Australia and America in seizing the potential of psychedelics for mental health innovation, the meeting was held in response to a letter from a group of cross-party MEPs calling for the EU to act fast on these therapies.

See also  EMA adds psychedelics to major depression guidelines

The MEPs wrote to the EMA and the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) to say the organizations need to play a more active role in the advancement of psychedelic medicines in Europe.

Highlighting that the recent shift in perspective towards psychedelics has garnered interest in Europe, the EMA has stated that concerns remain over challenges developers may face in meeting the scientific and regulatory expectations for receiving marketing authorisation for the medicines – holding the workshop as a starting point in working through these issues.

While the meeting marks one small, initial step for the EMA, the organisation’s interest in this developing field of research marks a giant leap for the advancement of the therapies in Europe.

Towards an EU regulatory framework for psychedelics

The meeting heard regulatory perspectives on psychedelic drugs in psychiatry from across Europe, Australia and America, as well as insights on the legal status of psychedelics and their impact on research.

Non-profit organisation PAREA highlighted how Europe is currently facing a mental health crisis with a desperate need for innovation in care, with not a single new medicine out of the 89 approved in 2022 targeting mental health.

The organisation emphasised the obstacles posed by regulation for scientific research and proposed a number of recommendations for a more supportive regulatory framework to help move psychedelic therapies forward, including:

  • Incentives such as regulatory protection: rescheduling psychedelic drugs to enable scientific research.
  • Enhanced EMA support: Utilising Europe’s PRIME scheme which focuses on medicines under development that are not yet authorised in the EU.
  • The establishment of an EU Commission on Novel Mental Health Therapies.
  • Accelerated assessments: Utilising Conditional Marketing Authorisation (CMA) and the EMA’s Adaptive Pathways programme for early patient access.
  • A more predictable reimbursement environment.

Speaking to Psychedelic Health, Tadeusz Hawrot, Founder and Director of PAREA, stated: “An importance of collaboration among different stakeholders felt central to the discussions, highlighting a need for joint effort to address the intricate issues surrounding psychedelic therapies.”

Building on the momentum created at the workshop, Hawrot said that PAREA will be exploring opportunities for a multistakeholder collaborative project as part of the Horizon Europe funding.

“The project would involve professional societies, patient groups, EMA and national competent authorities, addressing a number of most pressing topics related to psychedelic therapies at an intersection of regulation, science, and areas needed for implementing these therapies such as standards of care,” Hawrot explained.

“An upcoming EU Partnership on Brain Health will be an important opportunity to explore in this regard.”

Research and clinical trials

Further discussions focussed on methodological issues related to research and trials.

These surrounded issues with blinding and expectations, the importance of proper dosage justification and documenting dose-response relationships, as well as the need to investigate sub-psychedelic doses and their associations with psychoactive effects and neuroplasticity.

Hawrot commented: “In terms of some key areas addressed yesterday and today, discussion revolved around designing effective trials, the importance and type of therapeutic support, difficulties with using placebos, managing expectations, and how strict drug control policies are slowing down research.

“Exploring what can be standardised in trials, the crucial role of patient input and preferences, and the need for thorough aftercare provisions were further key points.”

The importance of Real World Evidence was also highlighted as a key path for advancing psychedelic therapies in Europe

Some implied next steps discussed were continuing dialogue between developers and regulators, seeking early feedback, and collaborating to address challenges in psychedelic drug development.

Patient representation and care

Ensuring the safe and effective use of psychedelic substances in clinical trials and real-world settings was also a main point of discussion, with patient representatives providing insight on their experience, as well as suggestions for patient care.

In particular, stakeholders including representatives of the Psychedelic Participant Advocacy Network (PsyPAN) highlighted the need for aftercare such as post-integrative therapy and peer support or professional guidance, however, it was also emphasised that these types of support are difficult to regulate.

The importance of patient involvement in research was also discussed, highlighting that patient involvement goes beyond study participation and includes a more active role in research design and decision-making.

Advancing innovation

Providing an environment where innovation can flourish will be vital for advancing psychedelics, and with companies already carrying out trails but hindered by strict regulations and expensive costs changes are needed sooner rather than later.

George McBride, Co-Founder of UK CMO Clerkenwell Health explained that the company is considering a significant investment into the EU to build out centres for the conduct of psychedelic research, querying the competitiveness of the EMA versus other jurisdictions such as the U.S FDA, Australia’s TGA, Health Canada and the UK’s MHRA.

EMA representatives provided assurance that the organisation is ready to be part of a collaborative and supportive effort to establish standards of care and standards for data gathering.

Speaking to Psychedelic Health, Stephen Murphy, CEO of PSYCH, commented: “This workshop is a key moment for the advancement of psychedelic medicines in Europe.

“The interest of the European Medicines Agency and the discussions in this week’s meeting highlights the organisation’s desire for innovation in mental healthcare and willingness to support psychedelic medicines through collaborative efforts.

“Taking action on psychedelic therapies now is a positive move towards preventative care in the area of mental health.

“We are pleased to see these developments at the start of 2024, which is set to be an important year for psychedelics across the globe.”

Harwot concluded: “The workshop made it clear that continuing conversations with regulators and developers and taking a measured approach to regulations are vital.

“It is very encouraging to see the degree of interest from EMA to explore the therapeutic potential of psychedelics and support developers in this field.”

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UK advisory body issues rapid response on psychedelics for anxiety

POST has confirmed it intends to publish a major briefing on psychedelic drugs to treat mental health conditions in 2024.

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Photo by Shreyas Sane on Unsplash

The UK’s independent Parliamentary Office of Science and Technology (POST) has issued a rapid response on psychedelic-assisted therapy for anxiety disorders.

The response is intended to inform policymakers on the topic as increasing research around psychedelics shows the compounds may hold promise as innovative treatments in the area of mental health.

The rapid response is the second response on psychedelics to come from POST – one of the first independent bodies of its kind in the world that sources independent analysis of public policy issues relating to science and tech for government.

See also  UK advisory body issues rapid response on psychedelic research

The response reads: “The social and economic costs of anxiety disorders in the UK are substantial, both for individuals and society. The Office for National Statistics reported that between 2019 and 2023, ‘depression, bad nerves and anxiety’ was the most prevalent health condition amongst those economically inactive because of long-term sickness.

“Beyond personal impacts, people with anxiety disorders account for a large amount of demand on healthcare. Consultations for GAD increased significantly between 1998 to 2018, and levels of anxiety were reported to increase during the COVID-19 pandemic.”

Responding to research and policy developments

Both rapid responses have been issued following a parliamentary debate discussing psilocybin access in May 2023.

The debate saw a group of crossparty MPs call for the rescheduling of psilocybin to remove barriers to research and demand an urgent review of the evidence for psilocybin’s current status as a Schedule 1 drug under the Misuse of Drugs Regulations 2001, “with a view to rescheduling”.

The Royal College of Psychiatrists, psychedelic access non-profit Heroic Hearts UK, and other leading mental health charities, also wrote letters to the Veterans Minister and the Minister of State for Crime, Policing and Fire, urging them to champion access for patients in the UK.

See also  UK MPs welcome psychedelic research, call for scheduling review

The rapid response covers psychedelics for anxiety including Treatment options for anxiety disorders, Lifestyle factors, Psychological treatments (psychotherapy), Pharmacological treatments, Psychedelic drugs for anxiety, Challenges in undertaking research involving psychedelics, Research examples and Ongoing research.

Joanna Neill, Professor of Psychopharmacology at the University of Manchester, acted as an external peer reviewer.

At the time of the first rapid response publication, speaking to Psychedelic Health, Neill commented: “It is very encouraging that Parliament is starting to engage with the enormous clinical potential of psychedelic medicine, particularly at a time when mental health disorders are at an all-time high.

“New therapies are urgently needed and psychedelics could provide just that. Given the weight of evidence presented in this new POST note, enabling safe patient access on the NHS must be a key priority for Parliament.”

POST has confirmed it intends to publish a major briefing on psychedelic drugs to treat mental health conditions in 2024.

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Now is the time for psychedelic access, says campaigner

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Now is the time for psychedelic access, says campaigner

Activists in Oakland recently filed a ballot put forward by Dave Hodges seeking to legalise safe and legal access to psychedelics for therapeutic uses. 

In the face of critics, Hodges has said now is the time for safe access to psychedelics.

The Psychedelic Wellness & Healing Initiative would enable the sale, possession and use of psychedelics for therapeutic purposes if passed. Psychedelics that would be allowed under the ballot include Psilocybin, MDMA, DMT, and Mescaline.

If passed, the initiative would give doctors and mental health specialists the right to recommend psychedelics to ease the debilitating symptoms of a range of problems, including obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), depression, anxiety, addiction, suicidality and traumatic brain injury (TBI), among others.

Hodges has said: “Now is the time for safe, controlled medical access for patients in need. The way to solve the problem is not by continuing to ignore it.” 

Hodges’ solution is to create a structure for use that includes proper dosages and access to experts who can help users benefit from appropriate treatment.

The updated initiative language emphasises safety, and gives doctors and mental health specialists the right to recommend psychedelics to ease the debilitating symptoms of a range of conditions.

Research by the University of Michigan and Columbia University shows non-LSD hallucinogenic use on the rise and Hodges has stated that increase means that the initiative providing guidelines for use is needed more than ever. 

Hodges said he hopes Californians will read the initiative, share their thoughts about it over the holiday week and offer feedback via the initiative website, PW4CA.com, by 27 November, 2023, the deadline for modifications.

“Now is the time to provide medical and therapeutic access to psychedelics,” Hodges said. “The way to do this is through the initiative.”

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Psychedelic Health is a journalist-led news site. Any views expressed by interviewees or commentators do not reflect our own. We do not provide medical advice or promote the personal use of psychedelic compounds. Please seek professional medical advice if you are concerned about any of the issues raised.

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