New findings on psychedelics will be presented at Neuroscience 2023, the annual meeting of the Society for Neuroscience, on Tuesday, 14 November.
While there is an increasing amount of research being published on psychedelics for the treatment of mental health indications, there are still questions about who will best respond to the treatments.
Currently, a number of researchers are working with animal models to answer questions about the therapeutic actions of psychedelic compounds.
Findings to be presented at Neuroscience 2023 show that:
– Psilocybin treatment had opposite effects on fear extinction learning in male and female rats (Phillip Zoladz, Ohio Northern University)
– Psychedelics including psilocybin and DMT may have different effects on fear learning dependent on dose and sex in mice (John Razidlo, University of Wisconsin, Madison)
– Psilocybin treatment reduced signs of physical withdrawal in a mouse model of nicotine addiction (Belle Buzzi, Virginia Commonwealth University)
Frederick Barrett, director of the Johns Hopkins Center for Psychedelic and Consciousness, who studies the mechanisms underlying the effects of psychedelic drugs, stated: “Studies suggest that certain psychedelic compounds show promise for treating a range of psychiatric disorders. The research presented today is crucial in understanding what factors may influence the efficacy of these compounds, including sex, dose, and timing of administration.”
Further research findings to be presented at the conference include:
– Research in animal models suggests that the effects of psychedelic compounds may be influenced by sex, dose, and other factors.
– Research in rats shows that psilocybin treatment can reduce physical symptoms of nicotine withdrawal.
Low-dose psilocybin sex-dependently enhances fear extinction in adult rats
(Phillip Zoladz)
As fear-related psychological disorders such as phobias and post-traumatic stress disorder are associated with excessive responses to fear memories, researchers treated rats with psilocybin after training them to associate a sound with a fear-inducing stimulus.
The team found that male rats learned that the tone no longer predicted the foot shock more quickly when treated with psilocybin. Conversely, female rats were slower to learn that the tone did not predict a shock when treated with the psychedelic.
The findings suggest that the ability of psilocybin to aid in behavioral therapies for fear-related psychological disorders may depend on the sex of the individual.
Differential modulation of threat assessment by psilocybin and DMT
(John Razidlo)
The psychedelic compounds psilocybin and DMT have been shown to exert rapid antidepressant effects, though the underlying mechanisms are not fully understood.
Researchers showed that psilocybin did not change the rate of fear learning or extinction of learned fear in mice.
Male mice that received psilocybin showed reduced contextual fear reinstatement when compared to female mice that received psilocybin, and mice treated with DMT showed impaired learning of fear extinction once the threat had been removed.
The team says that more research is needed to understand any time, dose, and sex-dependent effects of psychedelics, as well as their effects on fear-associated learning.
The effect of the psychedelic psilocybin on nicotine dependence behaviors in preclinical models (Belle Buzzi)
In a mouse model of nicotine dependence, animals that received psilocybin upon cessation of nicotine showed a reduction in signs of physical withdrawal.
In mice that were genetically modified to not express the serotonin 2A receptor, which is important for the subjective effects of psychedelics, psilocybin did not reduce nicotine withdrawal symptoms. The mice were also less sensitive to the rewarding effects of nicotine.
Results suggest that psychedelics such as psilocybin may be effective as a potential smoking cessation therapy, and that the serotonin 2A receptor is important for this effect.
