New data has shown that Amanita Muscaria extract (AME-1) has a potential new functional property – inhibiting human mast cell activation – which could hold promise for common inflammatory skin conditions.
Life sciences company, Psyched Wellness, has announced preliminary data revealing a potential new function property of AME-1. Released by the National Research Council of Canada (NRC), the data has demonstrated that the extract inhibits human connective-tissue mast cell activation.
Mast cells are located throughout the body, often closest to the skin, gut, brain, and lungs. They are a type of white blood cell and make up part of the human immune system. When activated, mast cells release pro-inflammatory mediators such as histamine and cytokines, contributing to inflammatory diseases such as atopic dermatitis and hives in the skin.
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The results demonstrate that pre-treatment of human mast cells with AME-1 extract inhibited their activation and partially blocked the release of pro-inflammatory mediators. This preliminary evidence suggests a potential key nutritional systematic and functional property of AME-1, with research continuing to further examine the mechanisms of this inhibition.
Scientific advisor to Psyched, Brian Tancowny, commented: “The first set of preliminary evidence in this investigative study of AME-1 reveals the discovery of a novel health and wellness benefit, as well as a new functional property.
“We are further investigating the potential of AME-1 to inhibit human mast cell activation and explore the potential of therapies to treat common skin conditions. It is very inspiring to have found an additional functional immune property of AME-1, and further work is being done to investigate this possibility, as well as potential neuroprotective properties of AME-1.”
The company has noted that the results of the research belong to Psyched, and the NRC does not endorse the findings or Psyched products.
